Pregabalin Sustained Release Tablets

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Therapeutic Indication

Neuropathic pain (diabetic neuropathy, post-herpetic neuralgia)
Adjunct therapy for partial seizures
Generalized anxiety disorder (GAD)
Fibromyalgia
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Pregabalin Sustained Release

Tablet

Pregabalin Sustained Release is an anticonvulsant and neuropathic pain agent. The SR formulation ensures steady plasma levels with once-daily dosing, improving compliance and therapeutic outcomes in chronic conditions.

Speciality Neurology | Psychiatry | Pain Management
Tags Neuropathic Pain | Anticonvulsant | Anxiety | Fibromyalgia
Strength
  • 300 mg
Packing Size
  • 10 Tablets

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Mechanism

Pregabalin binds to the α2-δ subunit of voltage-gated calcium channels in the CNS, reducing calcium influx and inhibiting release of excitatory neurotransmitters. This results in analgesic, anxiolytic, and anticonvulsant effects.

Pharmacokinetics

  • Bioavailability: ≥90%
  • Peak plasma concentration: ~5–6 hours (SR formulation)
  • Half-life: ~6 hours
  • Metabolism: Negligible hepatic metabolism
  • Excretion: Primarily unchanged via urine

Side Effects

  • Dizziness
  • Somnolence
  • Dry mouth
  • Peripheral edema
  • Weight gain
  • Rare: blurred vision, confusion

Contraindication

  • Hypersensitivity to Pregabalin
  • Severe renal impairment (dose adjustment required)
  • Pregnancy & lactation unless prescribed

Interaction

  • Opioids, benzodiazepines, alcohol: ↑ CNS depressant effects
  • Minimal CYP450 interactions

Warning and Precautions

  • Risk of drowsiness and dizziness
  • May cause withdrawal symptoms if stopped abruptly
  • Monitor renal function during long-term therapy

Dosage

As directed by the Physician.